Vitamin D and Respiratory Infections: What This Large UK Study Found

Vitamin D and Respiratory Infections: What This Large UK Study Found

A major analysis of UK Biobank data found that severe vitamin D deficiency was linked to a higher risk of being hospitalised for respiratory tract infections.

Vitamin D and Respiratory Infections: What This Large UK Study Found

Kids • Immune Health • Evidence

Vitamin D and Respiratory Infections: What This Large UK Study Found

A major analysis of UK Biobank data found that severe vitamin D deficiency was linked to a higher risk of being hospitalised for respiratory tract infections.

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Large cohort Hospital admissions UK data
 
Sunshine over a medow
Vitamin D levels often dip in winter — right when respiratory infections rise.

When we talk about vitamin D, we usually think “bones and teeth.” But vitamin D also plays a role in immune function — and low levels are common in the UK (especially in winter).

This study (published in The American Journal of Clinical Nutrition) looked at whether blood vitamin D levels were linked to respiratory tract infections (RTIs) serious enough to require hospital admission in the UK.

Key finding: People with severe vitamin D deficiency (serum 25(OH)D < 15 nmol/L) had a 33% higher hazard of RTI hospitalisation compared with those at ≥ 75 nmol/L.

Study at a glance

What they studied Who was included Outcome
Association between serum 25-hydroxyvitamin D (25(OH)D) and RTI hospital admission 36,258 UK Biobank participants (ethnically diverse sample) Hospital admission for respiratory tract infection (RTI)

What the researchers found

  • Each 10 nmol/L higher 25(OH)D was associated with a 4% lower hazard of RTI hospitalisation (HR 0.96; 95% CI 0.94–0.99).
  • Compared with ≥75 nmol/L, having <15 nmol/L was linked to a 33% higher hazard of RTI hospitalisation (HR 1.33; 95% CI 1.05–1.67).
  • Intermediate categories (15–74 nmol/L) were not statistically significant versus ≥75 nmol/L.
  • The authors tested whether the vitamin D–RTI relationship differed by ethnicity, and the interaction was not statistically significant.
Vitamin D supplement bottle on a countertop
In this study, the higher risk was concentrated in the “very low” vitamin D group.

Why this matters (and what it doesn’t prove)

The outcome here is important: hospital admissions (not self-reported “colds”). That makes the findings clinically meaningful — but it’s still an observational study, so it can’t prove that low vitamin D causes RTIs.

What it does suggest is a practical “watch-out”: severe deficiency may be a risk marker (and potentially a modifiable one). The authors also call for further studies to validate the findings and explore mechanisms across groups.

What can parents do in the UK?

While this specific study analysed UK adults, the practical UK takeaway remains relevant for families: vitamin D deficiency is common, and NHS guidance recommends a daily vitamin D supplement during autumn/winter for most people (and year-round for some groups).

Friendly reminder: For personalised advice (especially for babies, medical conditions, or higher-dose supplements), check with a GP or health visitor.

Simple foundations that help in real life:

  • Encourage outdoor play / daylight where possible
  • Build vitamin D-supportive habits into your routine (especially October–March)
  • If supplementing, follow NHS guidance for your child’s age group

References

  1. Bournot, A.R., et al. (2025). Association between serum 25-hydroxyvitamin D status and respiratory tract infections requiring hospital admission. The American Journal of Clinical Nutrition. DOI: 10.1016/j.ajcnut.2025.101179.
  2. Abstract / journal page (AJCN): https://ajcn.nutrition.org/article/S0002-9165(25)00771-3/abstract
  3. PubMed record: https://pubmed.ncbi.nlm.nih.gov/41475552/
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